Rosacea

There are some lotions or rosacea creams that can work wonders. Some acne rosacea creams to help improve the area , but not defeat the symptoms of rosacea. Talk to a dermatologist about a medication to help you deal with it. Rosacea is a skin condition that affects the skin, making it a reddish color, causing grain and increasing the thickness of the skin. While there is no cure for it, there are some ways to lessen its impact. The treatments for this condition can range from rosacea creams , medication or even surgery, in the event of rosacea has become a real problem. Each has its risks and benefits, you must consult your doctor dermatologist. One of the best things you can do is try to discover what things aggravate rosacea. Sometimes it may be a particular food, or exposure to certain elements, for some it may be heat and cold for others. They also help stress, anxiety and physical exercise. Fits your lifestyle so that you at least expose these triggers of rosacea. Tags: OTC rosace...

Acne rosacea is an inflammatory process that primarily affects the central part of the face. Observed almost exclusively in adults and rarely affects patients younger than 30 years. It is more common in women who have hormonal problems, digestive or nervous Acne rosacea is a type of acne that has little to do with acne vulgaris (common). Hence treatment is different from common acne. Acne rosacea is characterized by the appearance of pink spots on the face that can turn into boils and pimples. Unlike common acne, acne rosacea is not usually occur in people less than 30 years. Those who suffer from acne rosacea are adults, elderly, white-skinned enough and especially women who are reaching the age of menopause. It is very difficult to cure this type of acne completely, but if you can try to achieve significantly reduced. Besides genetic predisposition, some of the most common causes resulting in their appearance are: Prolonged exposure to the sun without protection. It is important to...

J Eur Acad Dermatol Venereol. 2009 Jun 8; Korting H, Schöllmann CRosacea is a common, often overlooked, chronic facial dermatosis characterized by intermittent periods of exacerbation and remission. Clinical subtypes and grading of the disease have been defined in the literature. On the basis of a genetic predisposition, there are several intrinsic and extrinsic factors possibly correlating with the phenotypic expression of the disease. Although rosacea cannot be cured, there are several recommended treatment strategies appropriate to control the corresponding symptoms/signs. In addition to adequate skin care, these include topical and systemic medications particularly suitable for the papulopustular subtype of rosacea with moderate to severe intensity. The most commonly used and most established therapeutic regimens are topical metronidazole and topical azelaic acid as well as oral doxycycline. Conventionally, 100-200 mg per day have been used. Today also a controlled release formul...

Topical treatment of acne rosacea , a chronic condition characterized by recurrent course for many years, is primarily based on metronidazole preparations. The aim of this study was to evaluate the effect of various acrylic acid polymers, in composition with methylcellulose on metronidazole release rate from hydrogels proposed for the treatment of acne rosacea . Viscosity and release studies using "Paddle over Disk" system with semipermeable membrane of MWCO 3500 were performed. Compositions of Carbopol 971P and methylcellulose revealed an increase in viscosity with increasing concentration of methylcellulose in the range of 17200-26166 mPa.s. In all the examined formulations, the release process was characterized by a two-stage course. Among bipolymeric formulations, the highest first-stage release rate of 9.18 x 10(-3) min(-1) was determined for the gel consisting of 2.00% Carbopol 980NF with 1.00% methylcellulose. The second-stage release rates ranged between 2.88 x 10(-3)...

Two large clinical trials have recently demonstrated the efficacy of a 40-mg controlled-release formulation of doxycycline in the treatment of rosacea , a dose well below the conventional level of 100 to 200 mg/d. Since no formal dose-response studies have been conducted, the authors analyzed phase 3 data to determine whether a dose-efficacy relationship exists. METHODS: Standard parametric regression analyses were used to estimate the correlations between dose (mg/kg body weight) and overall drug exposure (area under the curve [AUC]) in a phase 1 pharmacokinetic study and between dose and efficacy (mean change from baseline in total inflammatory lesion count at week 16) in 2 pooled phase 3 clinical efficacy studies. Additional regressions were run at each visit for the clinical efficacy studies to determine whether results differed across visits. A regression analysis was also performed in a subset of patients who showed a greater efficacy response. RESULTS: We found overall drug expo...

A rapid and simple method using an isocratic high-pressure liquid chromatography (HPLC) and UV detection for the determination of metronidazole in dermatological formulations is presented. Metronidazole samples were extracted with a solution composed of 60% methanol and 40% mobile phase by a procedure that can be completed in less than 10 min. Subsequent separation and quantification was accomplished in less than 20 min using reversed-phase HPLC with isocratic elution with 0.01% trifluoroacetic acid/acetonitrile (85:15%, vol/vol). Validation experiments confirmed the precision and accuracy of the method. When applied to a commercial metronidazole cream and gel formulation, recoveries of 100.4% for cream formulations and 102.3% for gel formulations were obtained. The method should facilitate studies of the formulation compatibility of metronidazole topical formulations with agents that may improve its clinical tolerability for treatment of rosacea . "Validation of a simple and rap...

The human skin is constantly exposed to microbial pathogens but infections only rarely occur. Innate cutaneous immunity is a primary system for protection against infection, and antimicrobial peptides (AMPs) expressed in skin are essential defence molecules. The AMPs include molecules such as the defensins that were first characterized for their antimicrobial properties as well as other peptides and proteins first known for their activity as chemokines, enzymes, enzyme inhibitors and neuropeptides. Cathelicidins are unique AMPs that act as defensive and signalling molecules. Two different pathways are involved in this function: cathelicidins have direct antimicrobial activity and they also initiate a host of cellular responses in cytokine release, inflammation and angiogenesis. Several skin diseases are associated with cathelicidin dysfunction. In atopic eczema, for example, cathelicidin expression is suppressed, whereas in rosacea cathelicidin peptides are abnormally processed to fo...