Surv Ophthalmol. 2009 May-Jun; 54(3): 321-38Donnenfeld E, Pflugfelder SCCyclosporine has been used successfully as a systemic immunomodulator for more than two decades, and numerous studies have investigated its mechanisms of action. In 2003 an ophthalmic formulation, cyclosporine 0.05% ophthalmic emulsion, was approved by the FDA to treat dry eye disease. Topical cyclosporine emulsion has also been investigated for treatment of other ocular surface disorders that may have an immune-based inflammatory component. In these trials, cyclosporine 0.05% ophthalmic emulsion has shown efficacy for management of posterior blepharitis, ocular rosacea, post-LASIK dry eye, contact lens intolerance, atopic keratoconjunctivitis, graft-versus-host disease, and herpetic stromal keratitis. As these disorders are often refractory to other available treatments, ophthalmic cyclosporine is a welcome nontoxic adjunct or replacement to potentially toxic topical or systemic immunosuppressive therapies.
Before And After: A Gorgeous Zen Bathroom Remodel " casacullen.com/2009/12/rwd-home-kitchen-redesign-before-and-after almost the same issue during my recent 1960s bath remodel, I house in prime vintage condition and wants to zen " We love when sustainability meets beauty in home renovations. And this Japanese-inspired bathroom remodel in by Weston Miles Architects is a prime example. These before photos show a pleasant enough bathroom with bright color and functional traditional cabinetry, though a small sink space, not-so eco-friendly materials, and dim lighting. This after photo shows an incredible remodel that makes use of traditional materials in a modern aesthetic. The focal point is this Japanese soaking tub that the client wanted, and the room grew around that. The room has been opened up for a step-in shower next to the tub, its warm lichen-green balanced against the natural wood of the tub and wood trim. This beautiful remodel exemplifie...