Skip to main content

Antimicrobial and antifungal activities of a novel cationic antimicrobial peptide, omiganan, in experimental skin colonisation models.

Int J Antimicrob Agents. 2009 Jun 11; Rubinchik E, Dugourd D, Algara T, Pasetka C, Friedland HDOmiganan pentahydrochloride is a novel, synthetic, cationic, antimicrobial peptide that is being developed for the prevention of catheter-related infections and the treatment of acne and rosacea. In this study, the efficacy of topical omiganan gel was evaluated in two skin colonisation models (ex vivo pig skin and in vivo guinea pig skin). When tested in the ex vivo pig skin colonisation model, omiganan 0.1-2% gels exhibited potent dose-dependent activity against Gram-positive and Gram-negative bacteria and yeasts; the maximum effect was observed at 1-2%. No significant difference was noted in activity toward meticillin-resistant and meticillin-sensitive Staphylococcus aureus, and drug activity was not affected by the inoculum size. The antimicrobial activity of omiganan 1% gel was rapid, with a 2.7log(10)colony-forming unit (CFU)/site reduction in Staphylococcus epidermidis counts at 1h post application and a 5.2log(10)CFU/site reduction at 24h. Additional studies in the guinea pig skin colonisation model confirmed the potent antimicrobial and antifungal activities of omiganan 1% gel. In conclusion, omiganan gels have been demonstrated to be rapidly bactericidal and fungicidal, with significant dose-dependent activity against a broad spectrum of infectious organisms. These results further confirm that the drug has the potential as a topical antimicrobial agent.

Popular posts from this blog

Prevalence Of And Associated Factors For Dry Eye In A Spanish adult population

To estimate the prevalence of dry eye and to investigate its relationship with lifestyle and systemic factors in a general adult population in north-western Spain. METHODS: A dry eye questionnaire was administered and objective tests were performed in 654 individuals [mean age (Standard deviation): 63.6 (14.4) years, range: 40-96, 37.2% males]. Subjects were considered symptomatic when one or more of the symptoms of the questionnaire were present often or all the time. Schirmer test or= 3 and fluorescein staining >or= 1 were considered indicative of signs. Dry eye was defined as the simultaneous presence of symptoms and at least one sign. A design based analysis was performed and all calculations were weighted to give unbiased estimates. RESULTS: Dry eye prevalence was 11.0% (95%confidence interval [CI] 8.6-13.3). Dry eye was found to be more frequent in women (11.9%, 95%CI 8.8-15.1) than in men (9.0%, 95%CI 5.3-12.6), and was significantly associated with aging (p autoimmune diseas...
Read more

Treatments For Rosacea

The specific treatments for rosacea is determined by your physician based on: Your age, general health and medical history. How advanced is the eruption. Tolerance to specific medications, procedures or therapies. Their expectations for the trajectory of the eruption. Your opinion or preference. Treatments for rosacea may include : Modifications to diet Antibiotics. Cortisone ointment. Laser surgery Use sunscreen with a sun protection factor Currently there are several treatments for rosacea are used, depending on the events that it has. At the initial stage, to prevent the dilation of blood vessels and the consequent need to avoid red hot environments, exposure to sunlight, extreme changes in temperature and food hot or too much seasoning. When pustules that resemble pimples, prescribed oral antibiotics such as tetracycline. Another alternative treatments for rosacea is the topical antibiotics such as metronidazole. Also is using retinoids, which regulate the sebum production of the ...
Read more

Photodynamic Therapy For Rosacea : Levulose

Levulose ®, which is frequently used in photodynamic therapy for rosacea , has shown that considerable improvement of mild to moderate acne. Photodynamic therapy for rosacea with levulose ® is often an effective alternative for patients whose skin over time has become resistant to treatment with antibiotics , and for those who want to avoid the hassles of applied topical ointments and creams. Generally used different types of light sources with levulose ® for treating acne, including systems for photodynamic therapy and BLU-U ® ClearLight ®. Both use blue light to treat the bacteria that cause acne. Omnilux ™ also offers a system of phototherapy with blue light and red, in addition to destroying bacteria, reduces inflammation and redness associated with acne lesions. The price of photodynamic therapy for rosacea depends on several factors, including the type and severity of the disorder and the region of the country where the procedure. The integrated packages can cost between USD 2...
Read more